ANDREA MASI v LEIGH HALFPENNYKRIS BURTON v DAN BIGGAR MARTIN CASTROGIOVANNI v GETHIN JENKINS ANDREO LO CICERO v ADAM JONES
THE versatile Masi is a former Six Nations player of the tournament and has been impressive in the colours of London Wasps in the Aviva Premiership this season. In Halfpenny he comes up against a contender for this season's award. Wales will need the Blues full-back in typical dead-eyed form with the boot as they look to put points between them and the Azzurri.
THE more predictable Burton is preferred to Luciano Orquera, who produced a dazzling man-of-the-match display against France in round one. Biggar will know plenty about his opponent from Heineken Cup action this season and will look to further his claims for an extended run in the No. 10 jersey for this tournament and beyond
CASTRO takes on the captaincy and the job of Azzurri talisman in the absence of Sergio Parisse. Italy need him not only to pressurise Jenkins at scrum-time, but also head the carrying and passion stakes. Jenkins was more like his old self in Paris and if Wales's set-piece can hold firm, will look to roam in the loose.
ANOTHER colossal front-row battle between two experienced Six Nations campaigners. Known as the Baron (he hails from Sicily) 36-year-old Lo Cicero became the first Italian to reach a century of caps against Scotland. Jones, meantime, will be keen to regain his scrummaging mojo after a rare off day in Paris.
A SOUTH SEAS flavour to a northern hemisphere battle. Fijian-born Vosawai has been given the unenviable task of filling the boots of Sergio Parisse and while he a strong carrier for Treviso he lacks the finesse of the Italian skipper. Faletau, born in Tonga, has enjoyed a strong start to the tournament, tackling hard and carrying with venom. Will flourish if the game opens up.